Significant improvement of systemic lupus erythematosus manifestation in children after autologous dendritic cell transfer: a case report and review of literature

Significant improvement of systemic lupus erythematosus manifestation in children after autologous dendritic cell transfer: a case report and review of literature

Blog Article

Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE).We reported a 13-year-old female SLE patient who presents with chronic arthritis accompanied by persistent fever, dyspnea, sleep disturbance, headache, stomatitis, rash, and muscle weakness.The supporting examinations showed abnormal blood cell 6.31/6GB counts, positive antinuclear antibody profile, Jandy JXi Parts serositis, and neuropathy.

Immunosuppressants failed to improve the condition.DC-based vaccine derived from autologous peripheral blood which was introduced with SARS-CoV-2 protein was given to this patient.There was a significant improvement in clinical and laboratory findings.

Thus, DC immunotherapy appears to be a potential novel therapy for SLE that needs to be studied.